Calvisi, D.F., Factor, V.M., Loi, R., and Thorgeirsson, S.S.:
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.
Cancer Research 61: 2085-2091, 2001.
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Chiou, S-K, Yoo, J., Loh, K.C., Guzman, R.C., Gopinath, G.R., Lakshmanaswamy, R., Chou, Y-C., Yang, J., Popescu, N.C., and Nandi, S.:
Identification of rat mammary tumor-1 gene (RMT-1), which is highly expressed in rat mammary tumors.
Cancer Letters 174: 45-55, 2001.
Durkin, M.E., Keck-Waggoner, C.L., Popescu, N.C. and Thorgeirsson, S.S.:
Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 (BEN) gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren Syndrome.
Genomics 73: 20-27, 2001.
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Elenbaas, B., Spirio, L., Koernerr, F., Fleming, M.D., Zimonjic, D.B., Donaher, J.L., Popescu, N.C., Hahn, W.C., and Weinberg, R.A.:
Human breast cancer cells generated by oncogenic transformation of primary epithelial cells.
Genes and Development 15: 50-65, 2001.
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Espinoza, L.A., Neto, J.B., Popescu, N.C. and Casartelli, C.:
Deletion 5p11 accompanied by mulitple numerical changes in testicular lymphoma.
Cancer Genetics and Cytogenetics 131: 79-81, 2001.
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Factor, V., Oliver, A. L., Thorgeirsson, S. S., Sonenshein, G. E., and Arsura, M.:
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of TGF-a/c-myc transgenic mice.
Hepatology 34: 32-41, 2001.
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Gelderblom, W.C.A., Abel S., Smuts C.M., Moritz W., Marnewick J., Marasas W.F.O., Lemmer, E.R.,and Ramljak, D.:
Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion.
Environmental Health Perspectives 109: 291-300, 2001.
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Gong, Q-H, Cho, J.W., Huang, T., Potter, C., Gholami, N., Basu, N.K., Kubota, S., Carvalho, S., Pennington, M.W., Popescu, N.C., and Owens, I.S.:
Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1gene complex locus.
Pharmacogenetics 11: 1-12, 2001
Gozukara, E. M., Khan, S. G., Metin, A., Emmert, S., Busch, D. B., Shahlavi, T., Coleman, D. M., Miller, M., Chinsomboon, N., Stefanini, M., and Kraemer, K. H.:
A stop codon in xeroderma pigmentosum group C families in Turkey and Italy: Molecular genetic evidence for a common ancestor.
Journal of Investigative Dermatology 117: 197-204, 2001.
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Herrera, B., Alvarez, A.M., Sanchez, A., Fernendez, M., Roncero, C., Benito, M., and Fabregat, I.:
Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.
FASEB J. 15: 741-751, 2001.
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Im, Y. H., Kim, H. T., Kim, I. Y., Factor, V. M., Hahm, K. B., Anzano, M., Jang, J. J., Flanders, K., Haines, D. C., Thorgeirsson, S. S., Sizeland, A., and Kim, S. J.:
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Cancer Research 61: 6665-6668, 2001.
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Kiss, A., Ortiz-Aguayo, R., Sharp, R., Merlino, G., Thorgeirsson, S. S., Gonzalez, F. J., and Peters, J. M.:
Evidence that reduction of hepatocyte growth facator (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Carcinogenesis 22: 975-979, 2001.
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Lorenzo, P.S., Kung, J.W., Bottorff, D.A., Garfield, S.H., Stone, J.C. and Blumberg, P.M.:
Phorbol Esters modulate the Ras exchange factor RasGRP3.
Cancer Research 61: 943-949, 2001.
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Mandal, A.K., Zhang, Z., Chou, J.Y., Zimonjic, D., Keck, C.L., Popescu, N.C. and Mukherjee, A.B.:
Molecular characterization of murine pancreatic phospholipase A(2).
DNA Cell Biology 20: 149-159, 2001.
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Nacro, K., Sigano, D.M., Yan, S., Nicklaus, M. C., Pearce, L.L., Lewin, N.E., Garfield, S.H., Blumberg, P.M. and Marquez, V.E.:
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
Journal of Medicinal Chemistry 44: 1892-1904, 2001.
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Nagy, P., Teramoto, T., Factor, V.M., Sanchez Munoz, A., Schnur, J., Paku, S. and Thorgeirsson, S.S.:
Reconstitution of liver mass via cellular hypertrophy in the rat.
Hepatology 33, 339-345, 2001.
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Niimi, T., Keck-Waggonner, C.L., Popescu, N. C., Zhou, Y., Levitt, R.C. and Kimura, S.:
UGRP-1 a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor.
Molecular Endocrinology 15: 2021 - 2036, 2001.
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Niimi, T., Nagashima, K., Ward, J.M., Minoo, P., Zimonjic, D.B., Popescu, N.C. and Kimura, S.:
Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.
Molecular and Cellular Biology 21: 7380 - 7390, 2001.
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Opavsky, R., Haviernik, P., Jurkovicova, D., Garin, M. T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bies, J., Garfield, S., Pastorekova, S., Oue, A., and Wolff, L.:
Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.
Journal of Biological Chemistry 276: 38795 - 38807, 2001.
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Paku, S., Schnur, J., Nagy, P., and Thorgeirsson, S.S.:
Origin and structural evolution of the early proliferating oval cells in rat liver.
American Journal of Pathology 158: 1313-1323, 2001.
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Podolski, J., Byrski, T., Zajaczek, S., Druck, T., Zimonjic, D.B., Popescu, N.C., Kata, G., Borowka, A., Gronwald, J., Lubinski, J. and Huebner, K.:
Characterization of a familial RCC-associated t(2;3) (q33;q21) chromosome translocation.
Journal of Human Genetics 46: 685-693, 2001.
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Prymakowksa-Bosak, M., Misteli, T., Herrera, J. E., Shirakawa, H., Birger, Y., Garfield, S., and Bustin, M.:
Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.
Molecular Cell Biology 21: 5169-5178, 2001.
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Shan, L., Rouhani, S.A., Schut, Herman, A.J., and Snyderwine, E.G.:
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cell.
Cell Growth and Differentiation 12: 649-656, 2001.
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Shao, L., Lewin, N. E., Lorenzo, P. S., Hu, Z., Enyedy, I. J., Garfield, S. H., Stone, J. C., Marner, F. J., Blumberg, P. M., and Wang, S.:
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.
Journal of Medicinal Chemistry 44: 3872-3880 , 2001.
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Simile, M., DeMiglio, M., Calvisi, D.F., Muroni, M., Frau, M., Asara, G., Daino, L., Deiana, L., Pascale, R., and Feo, F.:
Long-term dehydroepiandrosterone and 16 alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesion in liver of DEN-initiated rats.
Carcinogenesis 22: 301-308, 2001.
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Sun, Q.A., Zappacosta, F., Factor, V.M., Wirth, P.J., Hatfield, D.L., Gladyshev, V.N.:
Heterogeneity within animal thioredoxin reductases - Evidence for alternative first exon splicing.
Journal of Biological Chemistry 276: 3106-3114, 2001.
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Takebayashi, Y., Pourquier, P., Zimonjic, D.B., Nakayama, K., Emmert, S., Ueda, T., Urasaki, Y., Kanzaki, A., Akiyama, S., Popescu, N.C., Kraemer, K.H. and Pommier, Y.:
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.
Nature Medicine 7: 961-966, 2001.
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Thorgeirsson, S. S.:
Mechanism(s) of hepatocarcinogenesis: Insight from transgenic mouse models.
In: Arias, W., Boyer, J.L., Chisari, F.V., Fausto, N.R., Schachter, D., and Shafritz, D.A. (Ed.)
The Liver: Biology and Pathobiology, 4th edition. Lippincott Williams and Wilkins,
2001, pp. 1013-1028.
Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S., Bemmels, N. A., Garfield, S., Harris, C. C.:
Functional interaction of p53 and BLM DNA helicase in apoptosis.
Journal of Biological Chemistry 276: 32948-55, 2001.
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Yamasaki, T., Kurokawa, F., Shirahashi, H., Kusano, N., Hironaka, K., and Okita, K.:
Percutaneous radiofrequency ablation therapy with combined angiography and computed tomography assistance for patients with hepatocellular carcinoma.
Cancer 91: 1342-1348, 2001.
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Zhang, H., Barcelo, J.M., Lee, B., Kohlhagen, G., Zimonjic, D.B., Popescu, N.C., and Pommier, Y.:
Human mitochondrial topoisomerase I.
Proceedings of the National Academy of Sciences USA 98: 10608-10613, 2001.
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Zimonjic, D.B., Brooks, M.W., Popescu, N.C., Weinberg, R.A., and Hahn, W.C.:
Derivation of human tumor cells in vitro without widespread genomic instability.
Cancer Research 61: 8838-8844, 2001.
Zimonjic, D.B., Keck-Waggoner, C.L., and Popescu, N.C.:
Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma.
Leukemia 15: 1582-1588, 2001.
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Zimonjic, D.B., Zhang, H., Shan, Z., Factor, V., Trent, J., Thorgeirsson, S.S. and Popescu, N.C.:
DNA amplification associated with double minutes originating from chromosome 19 in mouse hepatocellular carcinoma.
Cytogenetics and Cell Genetic 93: 114-116, 2001.
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